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Accession number;02A0472904
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| Title;Anxiogenic Effect of Corticotropin-Releasing Factor 2 Receptor Antisense Oligonucleotides Infused into Rat Brain. |
| Author;
AKIYOSHI JOTARO
(Oitaidai Seishinshinkeika)
ISOGAWA KOICHI
(Oitaidai Seishinshinkeika)
MATSUSHITA YUKI
(Oitaidai Seishinshinkeika)
TSUTSUMI TAKASHI
(Oitaidai Seishinshinkeika)
HORINOUCHI YUKIKO
(Oitaidai Seishinshinkeika)
NAGAYAMA HARUO
(Oitaidai Seishinshinkeika)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.264-268(2002)
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| Figure&Table&Reference;FIG.5, REF.24 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Corticotropin-releasing factor(CRF) is widely distributed in the brain and coordinates behavioral responses to stress. Its receptor subtypes, CRF1 and CRF2, are expressed in the brain. For this study, we have tested the effect of a continuous infusion of CRF2 receptor antisense oligonucleotides into lateral ventricle on anxiety in rats. Our results indicate that CRF2 receptor antisense oligonucleotides produced anxiety in elevated plus maze, block and white box and conditioned fear stress in rats. No significant effect on general locomotor activity was no seen. These results indicate that stimulation of CRF2 receptors produces an anxiolytic effect. (author abst.) |
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