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Accession number;02A0472905
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| Title;Effects of corticosterone on firing activity of hippocampus CA1 pyramidal neurons. |
| Author;
MATSUZAKI YAMATO
(Nihondai I Seishinshinkeika)
SUZUKI TADASHI
(Nihondai I Seishinshinkeika)
MATSUDA EMI
(Nihondai I Seishinshinkeika)
TADA KOJI
(Nihondai I Seishinshinkeika)
KOJIMA TAKUYA
(Nihondai I Seishinshinkeika)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.269-272(2002)
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| Figure&Table&Reference;FIG.4, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Pyramidal neurons in the rat CA1 hippocampal area contain serotonin intracellular mineralcorticoid and glucocorticoid receptors. The pyramidal neurons also have inhibitory serotonin(5-HT) 1A receptors on cell membrane. In vivo electrophysiological experiments have demonstrated that corticosterone produce dysfunction of hippocampal 5-HT1A receptors. In the present study, we found that the acute administration of corticosterone had no effects on spontaneous firing activities of hippocampal CA1 pyramidal neurons in unanethetized, unrestrained rats. We also found that corticosterone pretreatment attenuated 5-HT1A receptor-mediated inhibitions of pyramidal neurons produced by buspirone. Present result further support the idea that stress-hormone produce 5-HT dysfunction in hippocampus. (author abst.) |
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