An immunohistochemical study on the brain mechanism of REM-sleep regulation.
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Accession number;02A0472909
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| Title;An immunohistochemical study on the brain mechanism of REM-sleep regulation. |
| Author;
MANDAI MASAHARU
(Osakaidai Shinkeiseishin'igaku)
URAKAMI TAKAHITO
(Osakaidai Shinkeiseishin'igaku)
MATSUMURA HITOSHI
(Osakaidai Shinkeiseishin'igaku)
YOSHIDA YASUSHI
(Osakaidai Shinkeiseishin'igaku)
EMURA NARUTSUGU
(Osakaidai Shinkeiseishin'igaku)
KURODA KENJI
(Osakaidai Shinkeiseishin'igaku)
YONEDA HIROSHI
(Osakaidai Shinkeiseishin'igaku)
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Journal Title;Annual Report of the Pharmacopsychiatry Research Foundation
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Journal Code:Y0939A
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ISSN:0286-7591
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VOL.;NO.34;PAGE.293-299(2002)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We found that NG-nitro-L-arginine methyl ester(L-NAME), an inhibitor of nitric oxide synthase (NOS), increased REM sleep, whereas N-ethyl-2-(1-ethyl-2-hydroxy-2-nitrosohydrazino)-ethanamine (NOC12), a nitric oxide(NO) donor compound, inhibited REM-sleep, when these compounds were administered to a diencephalic region. In the present study, we examined the distribution of neurons that change their activities along with the REM-sleep alteration caused by diencephalic administration of these compounds by use of immunohistochemistry with antibodies raised against Fos related antigen(FRA). The number of FRA-immunoreactive cells in rats treated with NOC12 was decreased than that in control rats in the paraventricular thalamic nucleus-anterior part(PVA) and suprachiasmatic nucleus(SCh). On the other hand, FRA immunoreactive cells were seen more abundantly in the paraventricular hypothalamic nucleus-posterior part(PaPo), PVA, SCh, and so forth in rats treated with L-NAME when compared with the immunoreactivity seen in the control rats. Our preliminary results suggested that neurons in specific areas in the thalamus and hypothalamus play important roles in the regulation of REM-sleep. (author abst.) |
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