A report of three cases of diabetic nephropathy satisfactorily treated with traditional herbal medicine. Clinical evaluation of the effect of traditional herbal medicines containing Daio(Rhei Rhizoam) on the progression of diabetic nephropathy with overt proteinuria.
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Accession number;02A0476295
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| Title;A report of three cases of diabetic nephropathy satisfactorily treated with traditional herbal medicine. Clinical evaluation of the effect of traditional herbal medicines containing Daio(Rhei Rhizoam) on the progression of diabetic nephropathy with overt proteinuria. |
| Author;
GOTO H
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.2;PAGE.37-45(2002)
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| Figure&Table&Reference;FIG.4, TBL.4, REF.21 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We reported that three cases of diabetic nephropathy, who had overt proteinuria, were treated satisfactorily not only for their symptoms but also renal nephropathy with traditional herbal medicine over a long term. In Case 1, the level of S-Cr had changed from 1.2 to 2.0mg/dl over 98 months, in Case 2 from 0.9 to 1.9mg/dl over 70 months, and in Case 3 from 1.1 to 2.9mg/dl over 81 months, acceptably moderate increases, meaning that the progression of their renal insufficiency was controlled over the long term. We also studied the effect of traditional herbal medicines containing Daio(Rhei Rhizoma) on the long-term progression of diabetic nephropathy with overt proteinuria in 8 patients [mean age 60(45-73) years; duration of diabetes 18(7-36) years]. An average of 7.4(5-12) kinds of traditional herbal prescriptions was used for each patient. At the beginning of the study mean HbAlc was 8.2% and mean serum creatinine was 1.0.+-.0.3mg/dl. After a mean of 107.+-.25 months, the mean serum creatinine level had significantly increased to 4.8.+-.2.6mg/dl. The mean serum creatinine levels of 5 patients not advancing to dialysis treatment increased from 1.2.+-.0.3 to 3.2.+-.1.0mg/dl, and those of 3 patients requiring dialysis increased from 0.8.+-.0.1 to 7.5.+-.2.1mg/dl. The mean rate of decline of creatinine clearance in the measurable 4 patients was 0.78.+-.0.40ml/min/month. Diabetic nephropathy with overt proteinuria is reported to develop into renal failure after 6-7 years. In this study, traditional herbal medicines with Daio were considered to be effective in prolonging the pre-dialysis period of diabetic nephropathy. (author abst.) |
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