Inhibitory effects of Cinnamomi Cortex and cinnamaldehyde on oxygen-derived free radical-induced vasocontraction in isolated aorta of spontaneously hypertensive rats.
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Accession number;02A0476297
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| Title;Inhibitory effects of Cinnamomi Cortex and cinnamaldehyde on oxygen-derived free radical-induced vasocontraction in isolated aorta of spontaneously hypertensive rats. |
| Author;
KASAHARA Y
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
GOTO H
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
SHIMADA Y
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
SEKIYA N
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
YANG Q
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TERASAWA K
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.2;PAGE.51-57(2002)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.24 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We examined the inhibiting effect of Cinnamomi Cortex extract(CCE) and cinnamaldehyde(CA) against vasocontraction induced by oxygen-derived free radicals produced by the xanthine-xanthine oxidase(XOP) system in the thoracic aortic ring of the spontaneously hypertensive rat(SHR), using the organ bath method in vitro. The vasocontraction induced by xanthine-XOD in the CCE(10-4g/ml) and CA(10-4M) treatment groups were significantly lower than that in the control group. Further, the amounts of thromboxane B2(TXB2) produced in the vasocontractive response in the CCE(10-4g/ml) and CA(10-4M) treatment groups were significantly lower than that in the control group. For the purpose of examining the mechanism of the inhibiting effect of CA against thromboxane production, the inhibiting effect of CA against the vasocontraction induced by phospholipase A2(PLA2) was examined. The vasocontraction induced by PLA2 in the CA(10-4M) treatment group was significantly lower than that in the control group. Moreover, the amount of TXB2 produced by the vasocontractive response in the CA(10-4M) treatment group was significantly lower than that in the control group. From the above findings, it is suggested that Cinnamomi Cortex is an agent which exerts an inhibitory effect on the vasocontractive factor(TXA2) in vitro. (author abst.) |
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