Clinical Study of EN036 for Non-specific Menopausal Complaints.
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Accession number;02A0532075
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| Title;Clinical Study of EN036 for Non-specific Menopausal Complaints. |
| Author;
YOSHIOKA TAMOTSU
(Center for Adult Dis., Kurashiki)
NISHIUCHI TOSHIFUMI
(Center for Adult Dis., Kurashiki)
AKIMOTO TERUHISA
(Okayama Saiseikai General Hospital)
YOSHIDA NOBUTAKA
(Hiroshimashiminbyoin Sanfujinka)
KANESHIGE EMIKO
(Okayamachuobyoin Sanfujinka)
HASEGAWA YASUTAKA
(Chudenbyoin Sanfujinka)
KAWAHARA YOSHIFUMI
(Tsuyamachuobyoin Sanfujinka)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.5;PAGE.401-414(2002)
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| Figure&Table&Reference;FIG.1, TBL.12, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;A clinical study was conducted to investigate the usefulness of EN036, a vitamin E (d-.ALPHA.-tocopherol) preparation containing Japanese angelica root extract and red ginseng root extract, for indefinite climacteric complaints. A total of 107 patients were studied. The main findings were as follows. 1. The improvement rating by symptom was "slightly improved" or better in 83.3% of patients for hot flashes, 64.4% for feeling of cold, 66.2% for shoulder stiffness, 63.0% for numbness in the hands and feet, 73.4% for heavy feeling in the head, 61.6% for lassitude, and 65.0% for perspiration. 2. The global improvement rating was "slightly improved" or better in 93.6% of patients. 3. Adverse reactions occurred in 10.1% of patients, and none were serious. 4. The overall safety rating showed "no problems" with safety in 90.9% of patients. 5. The drug was "slightly useful" or better in 87.8% of patients. It is concluded from the above results that EN036 is a useful drug for alleviating indefinite climacteric complaints. (author abst.) |
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