Bioorganic Studies on DNA and Design of DNA Targeting Molecules.

Accession number;02A0421400
Title;Bioorganic Studies on DNA and Design of DNA Targeting Molecules.
Author; SAITO ISAO (Kyoto Univ., Grad. Sch.)
Journal Title;Nippon Kagakkai Koen Yokoshu
Journal Code:S0493A
ISSN:0285-7626
VOL.81st;NO.1;PAGE.A.3(2002)
Figure&Table&Reference;
Pub. Country;Japan
Language;Japanese
Abstract;Following topics on chemical genomics will be presented. These include, 1) design and synthesis of tailor-made DNA alkylating agents possessing anticancer activity, 2) molecular design of DNA mismatch recognition molecules and its use for SNPs detection, 3) development of new methods for light-triggered gene manipulation, 4) mechanistic studies of DNA-mediated electron transfer process, 5) design of artificial DNAs of novel functions such as parallel DNA, 6) mapping of HOMO of duplex DNA. (author abst.)