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Accession number;02A0421427
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| Title;Structural Genomics of protein transport and glycosylation using X-ray crystallography. |
| Author;
WAKATSUKI SOICHI
(High Energy Accelerator Res. Organization, Inst. Materials Structure Sci.)
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Journal Title;Nippon Kagakkai Koen Yokoshu
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Journal Code:S0493A
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ISSN:0285-7626
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VOL.81st;NO.1;PAGE.A.22(2002)
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| Figure&Table&Reference;FIG.2 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Following the recent progress of the human and other genome projects, a number of post-genomic projects have been started with the aim to extract maximum out of genome information and to use them in the enhancement of human health. Structural genomics constitutes one of the most important post-genomic sciences. It is an endeavor to determine protein structures en masse in a systematic way using X-ray and NMR techniques. In particular, highly collimated and energy-tunable X-ray photons from modern synchrotron sources have revolutionized the field by making it possible to determine accurate structures from small crystals of large protein complexes. At the Photon Factory, we are proposing a structural genomics project targeted to protein transport and glycosylation with a strong emphasis on technological development for high-throughput structure determination. Recent structural results on a key human protein involved in the transport of glycosylated proteins along with examples of high throughput technologies will be described. (author abst.) |
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