|
Accession number;02A0476590
|
| Title;Elevation of HDL-cholesterol. |
| Author;
YAMASHITA SHIZUYA
(Osakadai Daigakuin'igakukeikenkyuka Bunshiseigyonaikagaku)
|
Journal Title;Prog Med
|
Journal Code:F0664B
|
ISSN:0287-3648
|
|
VOL.22;NO.4;PAGE.947-953(2002)
|
| Figure&Table&Reference;FIG.4, TBL.1, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The elevation of serum HDL-cholesterol is called"hyperalphalipoproteinemia", however the pathophysiological mechanisms for this condition are heterogeneous. It is caused by a variety of qualitative and quantitative abnormalities of molecules involved in the reverse cholesterol transport, a major protective system against atherosclerosis. Especially, plasma cholesteryl ester transfer protein(CETP) deficiency contributes to more than half of a marked hyperalphalipoproteinemia in the Japanese population. CETP deficiency is not a "longevity syndrome", but patients with this disease are accompanied by an enhanced atherosclerosis. Thus, hyperalphalipoproteinemia is a state of impaired reverse cholesterol transport in humans. (author abst.) |
|
|
|
Related Articles;
|
