Correlation between Intellectual Level at Five Years of Age and Serum Phenylalanine Concentrations at Various Age Periods.
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Accession number;02A0492511
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| Title;Correlation between Intellectual Level at Five Years of Age and Serum Phenylalanine Concentrations at Various Age Periods. |
| Author;
MOROISHI KAZUE
(Kurume Univ., Fac. of Med.)
YOSHIDA ICHIRO
(Kurume Univ., Fac. of Med.)
HARADA EIMEI
(Kurume Univ., Fac. of Med.)
KAWANO GO
(Kurume Univ., Fac. of Med.)
YOSHINO MAKOTO
(Kurume Univ., Fac. of Med.)
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Journal Title;Journal of the Japan Pediatric Society
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Journal Code:F0896A
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ISSN:0001-6543
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VOL.106;NO.5;PAGE.639-643(2002)
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| Figure&Table&Reference;FIG.1, TBL.3, REF.17 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;To determine whether or not there is any specific age period when intellectual level is particularly affected by hyperphenylalaninemia, the correlation between the intelligence quotient (IQ) score at five years of age and the serum phenylalanine concentration ([s-Phe]) at each of five age periods was studied in 12 patients with phenylketonuria. The five age periods were: Period 0, before therapy, Period I, initiation of therapy.LEQ.-6 months, Period II, 6 months.LEQ.-12 months, Period III, 12 months.LEQ.-3 years, and Period IV, 3 years.LEQ.-6years. The mean IQ score in the 12 patients was 110.+-.16 at five years of age. The IQ score was.GEQ.120 in five (Group A), 90.LEQ.-120 in six (Group B), and 85 in the other one. The mean [s-Phe] was significantly lower in Group A than in Group B, in Period IV. Simple regression analysis revealed that the IQ score was significantly correlated with the overall mean [s-Phe] in Period IV, and multiple regression analysis found that it was correlated with the mean [s-Phe] in Periods IV, III and I, in the order of decreasing significance. These observations indicate that the IQ score was most correlated with the most recent mean [s-Phe]. (author abst.) |
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