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Accession number;02A0492512
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| Title;Influence of Iodine Excess on Neonatal Thyroid Function. |
| Author;
ASAKURA YUMI
(Kanagawa Child. Med. Center)
ADACHI MASANORI
(Kanagawa Child. Med. Center)
TACHIBANA KATSUHIKO
(Kanagawa Child. Med. Center)
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Journal Title;Journal of the Japan Pediatric Society
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Journal Code:F0896A
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ISSN:0001-6543
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VOL.106;NO.5;PAGE.644-649(2002)
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| Figure&Table&Reference;FIG.4, TBL.2, REF.16 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Iodine excess is known to be one of the most frequent causes of transient hypothyroidism. To evaluate the influence of iodine excess, infants with transient neonatal hypothyroidism detected by neonatal screening were studied. One hundred and fifty infants with elevated TSH and/or low fT4 out of 440 referred to Kanagawa children' s Medical center for the evaluation of congenital hypothyroidism were studied. Serum iodine concentration was measured in 122 of them at the first visit. Fifty-eight were confirmed as transient hypothyroidism after re-evaluation at 3 years old. In 20 of 58, iodine excess was strongly suspected of the causes of transient impairment of thyroid function. The development of iodine-induced hypothyroidism was associated with iodine-containing anti septic agents applied to both mothers and neonates, contrast agents including hysterosalpingography before pregnancy, inappropriate administration of iodine-containing medications to mothers and over intake of seaweed during pregnancy. Severe and prolonged iodine overload resulted in overt neonatal hypothyroidism requiring l-thyroxine supplement. Obstetricians and pediatricians should understand that fetus and neonate is vulnerable and at great risk for iodine induced hypothyroidism and that inappropriate iodine-containing medications during this period should be avoided. (author abst.) |
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