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Accession number;02A0601164
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| Title;Organ selectivity of Juzen-taiho-to and Ninjin-yoei-to in the expression of anti-metastatic efficacy. |
| Author;
MATSUO M
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TANI T
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
SAIKI I
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.3;PAGE.93-97(2002)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;We investigated the inhibitory effect of oral administration of Juzen-taiho-to and Ninjin-yoei-to on liver metastasis caused by intraportal vein injection of colon 26-L5 cells and lung metastasis by intravenous injection of same tumor cells. Juzen-taiho-to significantly inhibited liver metastasis but not lung metastasis. In contrast, Ninjin-yoei-to was effective at inhibiting lung metastasis but not liver metastasis. In the experimental liver and lung metastases model using same tumor in syngeneic mice system, oral administration of both formulations showed a differential pattern with organ selectivity for the expression of anti-metastatic effects. These results suggest that the different expression of the anti-metastatic effects of both Kampo medicines on tumor metastasis are partly based on the medicinal guides according to the theory of Jing and Lun(Inkei-hoshi) formed in the 13th century. (author abst.) |
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