Effects of Shojoki-to(Xiao-Cheng-Qi-Tang) on colonic circular muscle motility in conscious rat: Role of immature orange and magnolia bark in the prescription.
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Accession number;02A0601165
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| Title;Effects of Shojoki-to(Xiao-Cheng-Qi-Tang) on colonic circular muscle motility in conscious rat: Role of immature orange and magnolia bark in the prescription. |
| Author;
YAGI T
(Mukogawa Women's Univ., Hyogo, Jpn)
YAMAUCHI K
(Mukogawa Women's Univ., Hyogo, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.3;PAGE.98-104(2002)
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| Figure&Table&Reference;FIG.2, TBL.2, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;This study was performed to clarify the purgative activity and effect of Shojoki-to on rat colonic circular muscle motility by means of chronically implanted force transducers in conscious rats. Also examined was the composition of Shojoki-to, i.e., the significance of combining rhubarb, immature orange and magnolia bark for its preparation. Rhubarb, a laxative, is known to affect large intestinal motility. It significantly decreased the number of contractile waves and increased the percentages of high-amplitude contractions and low-amplitude contractions to the total contractions of rat colonic circular muscle at the onset of diarrhoea. In Shojoki-to, the purgative activity of rhubarb was significantly potentiated. The preparation also significantly prevented some rhubarb-induced effects on the colonic motility such as a decrease in the number of contractile waves, and increased the high-amplitude contractions in comparison with rhubarb alone after the onset of diarrhoea. Combined administration of either immature orange or magnolia bark with rhubarb did not reproduce the effect of Shojoki-to on colonic circular muscle motility. We concluded that in Shojoki-to, immature orange and magnolia bark activate colonic muscle motility, consequently preventing the rhubarb-induced disturbance of the regular spiking activity of colonic circular muscle, such as a decrease in the number of contractile waves. These effects may contribute to its potentiating effect on the purgative activity of rhubarb. (author abst.) |
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