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Accession number;02A0601167
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| Title;Variation of sennoside A content and purgative activity during preparation of rhubarb decoction. |
| Author;
OKAMURA NOBUYUKI
(Fukuyamadai Yaku Shoyakugaku)
ABO NAOMI
(Fukuyamadai Yaku Shoyakugaku)
AONO MIO
(Fukuyamadai Yaku Shoyakugaku)
EGUCHI TOMOYORI
(Fukuyamadai Yaku Shoyakugaku)
YOSHII HISANO
(Fukuyamadai Yaku Shoyakugaku)
ONO YUKIO
(Fukuyamadai Yaku Shoyakugaku)
YAGI AKIRA
(Fukuyamadai Yaku Shoyakugaku)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.3;PAGE.114-118(2002)
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| Figure&Table&Reference;FIG.5, REF.8 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Daio-kanzo-to is a Kampo medicine for acute and chronic constipation which consists of a combination of rhubarb and glycyrrhiza. The contribution of rhubarb is to provide a purgative effect, due to the presence of sennosides. Sennoside A is known to decompose on heating during decoction. Therefore, it is said that Kampo decoctions containing rhubarb rather do not have to be boiled for a long time when targeting the purgative activity of sennoside A. This study was performed to clarify the relationship between decocting times of rhubarb and purgative activity. The variation of sennoside A content in rhubarb during the decocting times of 5 to 240min was shown to be almost the same as that of Daio-kanzo-to. Compared to sennoside A content between powder and cut rhubarb during the period of decoction, the time when the maximum dissolution was reached had significant differences(powder: 10min, cut: 40min). Each purgative activity of powder and cut rhubarb decoctions was in proportion to sennoside A content. Kampo decoctions are generally prepared with cut crude drugs. Therefore, we concluded that usual decoction(40min) is most suitable for Kampo medicines containing rhubarb to use for constipation. (author abst.) |
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