Efficacy and Safety of Combination Therapy with Losartan and Hydrochlorothiazide in Elderly Hypertension.
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Accession number;02A0372072
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| Title;Efficacy and Safety of Combination Therapy with Losartan and Hydrochlorothiazide in Elderly Hypertension. |
| Author;
ETO KIMIKA
(Kyudai Daigakuin Byotaikinonaikagaku)
TSUCHIBASHI TAKUYA
(Kyudai Daigakuin Byotaikinonaikagaku)
ABE ISAO
(Kyudai Daigakuin Byotaikinonaikagaku)
IIDA MITSUO
(Kyudai Daigakuin Byotaikinonaikagaku)
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Journal Title;Japanese Journal of Geriatrics
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Journal Code:Z0680A
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ISSN:0300-9173
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VOL.39;NO.2;PAGE.181-186(2002)
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| Figure&Table&Reference;FIG.3, TBL.2, REF.20 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We examined the effect and safety of combinatio therapy with low-dose diuretics(hydrochlorothiazide:HCTZ) and angiotensin II receptor antagonist (losartan) in elderly cases of hypertension, using ambulatory blood pressure monitoring(ABPM). Elderly hypertensive patients(mean age 75.+-.2 years) were treated with either losartan(25-50mg/day) or HCTZ(12.5mg/day) for at least 4 weeks, and then 24-hour blood pressure(BP) was measured by ABPM. Combination therapy with addition of other drug was initiated in 14 patients whose 24-hour systolic BP or daytime systolic BP was over 140mmHg(160mmHg for the patients of 80 years or older). After 4 weeks of the combination therapy, ABPM was repeated. Blood cell count and blood chemistry were also done before and after initiation of combination therapy. In the losartanpreceding group(n=9), the combination therapy with HCTZ reduced 24-hour BP by 19.3.+-.2.3/6.6.+-.2.3mmHg. Similarly, daytime and nighttime BP decreased by 21.4.+-.4/8.4.+-.2.8mmHg and 15.2.+-.4/4.2.+-.2.4mmHg, respectively. In the HCTZ-preceding group, the combination with losartan also decreased 24-hour BP by 12.2.+-.4.8/3.4.+-.1.4mmHg.The decreases of daytime and nighttime BP were 13.8.+-.6.6/4.+-.1.1mmHg and 10.+-.4.7/3.+-.2.4mmHg, respectively. Heart rate did not change with combination therapy in the losartan-preceding group, while heart rate during daytime tended to decrease by addition of losartan in the HCTZ-preceding group(3.8.+-.1.7/min). Serum electrolytes, uric acid, lipids, renal function and body weight did not change during the study period. Thus, combination therapy of losartan/hydrochlorothiazide seems useful in the treatment of elderly hypertension, showing additive BP lowering effect without metabolic adverse effects. (author abst.) |
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