Science Links Japan | Effects of Carvedilol on the Hemodymamics and its Tolerance in Elderly Patients.

Effects of Carvedilol on the Hemodymamics and its Tolerance in Elderly Patients.

Accession number;02A0372073

Title;Effects of Carvedilol on the Hemodymamics and its Tolerance in Elderly Patients.

Author; ASAI TOSHINOBU (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku)) KUZUYA MASAFUMI (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku)) KOIKE AKIHIKO (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku)) KANDA SHIGERU (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku)) MAEDA KEIKO (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku)) IGUCHI AKIHISA (Nagoyadai Daigakuin I Igakukenkyuka Kenkoshakaiigakusenko Hatsuikukareiigaku(ronen'igaku))

Journal Title;Japanese Journal of Geriatrics

Journal Code:Z0680A

ISSN:0300-9173

VOL.39;NO.2;PAGE.187-192(2002)

Figure&Table&Reference;FIG.3, TBL.3, REF.14

Pub. Country;Japan

Language;Japanese

Abstract;Clinical trials have shown that beta-blockers can produce symptomatic improvement and decrease the risk of death in chronic heart failure patients. However, the side effects of beta-blockers including worsening heart failure, AV-block, contracting peripheral vessels and unfavorable effects on glucose and cholesterol metabolism tend to make physicians hesiate to prescribe beta-blockers for elderly patients. Carvedilol is a novel non-selective beta-blocker without intrinsic sympathomimetic activity(ISA) and has vasodilating effect through blocking alpha 1 receptor. We examined the effects of carvedilol on cardiac parameters in order to clarify whether beta-blocker may affect left ventricular function in elderly Japanese patients with hypertension, angina pectoris, or both. We examined the hemodynamic effect of carvedilol in 16 patients with hypertension, angina patients or both, aged 65 and over(75.5.+-.5.6y.o.). After 12 weeks treatment with 10-20mg daily oral administration, echocardiography was performed and hemodynamic parameters were calculated to evaluate their cardiac functions. Blood pressure was significantly decreased, especially in systolic pressure(163.8/87.6.+-.15.6/11.2mmHg to 141.6/76.9.+-.16.6/11.7mmHg, p<0.001/p<0.01, respectively). Ejection fraction increase(65.8.+-.11.8% to 71.2.+-.11.4%, p<0.05) accompanied heart rate decrease(72.0.+-.161bpm to 63.9.+-.11.4bpm, p<0.05). Carvedilol increased ejection fraction and decreased blood pressure safely in elderly patients with hypertension, angina pectoris, or both. Taking the condition of each patient into consideration, alpha-beta-blocker can be beneficial in elder patients. (author abst.)

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