Science Links Japan | Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propylthiouracil and Thiamazole.

Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propylthiouracil and Thiamazole.

Accession number;02A0594716

Title;Prevalence of Serum Anti-Myeloperoxidase Antineutrophil Cytoplasmic Antibodies (MPO-ANCA) in Patients with Graves' Disease Treated with Propylthiouracil and Thiamazole.

Author; WADA N (Sapporo City General Hospital, Sapporo, Jpn) MUKAI M (Sapporo City General Hospital, Sapporo, Jpn) KOHNO M (Sapporo City General Hospital, Sapporo, Jpn) NOTOYA A (Sapporo City General Hospital, Sapporo, Jpn) ITO T (Sapporo City General Hospital, Sapporo, Jpn) YOSHIOKA N (Sapporo City General Hospital, Sapporo, Jpn)

Journal Title;Endocr J

Journal Code:F0625A

ISSN:0918-8959

VOL.49;NO.3;PAGE.329-334(2002)

Figure&Table&Reference;TBL.4, REF.32

Pub. Country;Japan

Language;English

Abstract;Patients with Graves' disease (n=61) treated wth propylthiouracil(PTU) or thiamazole (MMI) were studied retrospectively to investigate differences in the prevalence of anti-myeloperoxidase anti-neutrophil cytoplasmic antibodies (MPO-ANCA) in relation to treatment with anti-thyroid drugs. The patients were divided into two groups: PTU-treated group (n=32) and MMI-treated group (n=29). There were no significant differences between the two groups in terms of age, gender distribution, or duration of treatment. In the PTU group, 8/32 (25%) patients were positive for MPO-ANCA, whereas in the MMI group, 1/29 (3.4%) patients were positive. There were no significant differences in age, duration, or dosage between the MPO-ANCA positive and negative patients. Most of the MPO-ANCA positive patients were asymptomatic, except for two patients in whom rheumatic arthritis or membranous glomerulonephritis developed. None of the MPO-ANCA positive patients were diagnosed as having classical ANCA-associated vasculitis. Thus, there is a high frequency of MPO-ANCA in patients with Graves' disease treated with PTU, compared with patients treated with MMI, although classical ANCA-associated vasculitis develops in only a few MPO-ANCA positive patients. (author abst.)

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