Time-Dependent Effects of Vitamin K2 (Menatetrenone) on Bone Metabolism in Postmenopausal Women.
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Accession number;02A0594721
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| Title;Time-Dependent Effects of Vitamin K2 (Menatetrenone) on Bone Metabolism in Postmenopausal Women. |
| Author;
OZURU R
(Kobe Univ. School Of Medicine, Kobe, Jpn)
SUGIMOTO T
(Kobe Univ. School Of Medicine, Kobe, Jpn)
YAMAGUCHI T
(Kobe Univ. School Of Medicine, Kobe, Jpn)
CHIHARA K
(Kobe Univ. School Of Medicine, Kobe, Jpn)
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Journal Title;Endocr J
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Journal Code:F0625A
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ISSN:0918-8959
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VOL.49;NO.3;PAGE.363-370(2002)
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| Figure&Table&Reference;FIG.2, TBL.3, REF.48 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Vitamin K is known to mediate carboxylation of glutamyl residues of osteocalcin. We evaluated the effects of vitamin K2 (menatetrenone) treatment (45mg/day) for 48 weeks on the markers of bone formation and resorption, bone mineral density(BMD), and the incidence of vertebral fractures in 34 Japanese postmenopausal women (aged 48-82 years). Serum levels of alkaline phosphatase(ALP) increased gradually and became significant at 48 weeks after menatetrenone treatment, while urinary excretion of deoxypyridinoline(DPD) decreased transiently but significantly at 4 weeks. Serum levels of both intact osteocalcin(OC) and carboxylated OC (Gla-OC) increased rapidly and significantly within 4 weeks and sustained their high values up to 48 weeks after the treatment, while those of undercarboxylated OC (Glu-OC) decreased reciprocally. These results can be interpreted to suggest that Glu-OC was converted to Gla-OC in vivo. On the other hand, lumbar BMD values showed no significant change and only one subject with a previous vertebral fracture had one newly occurring vertebral fracture. These results indicate that menatetrenone treatment of postmenopausal women constantly elevates bone formation markers as well as converts Glu-OC to Gla-OC. Thus, vitamin K2 treatment may promote bone formation, at least as measured biochemically in these subjects. (author abst.) |
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