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TOP > J-EAST > List of Journal Titles (F) > Fusso Kagaku Toronkai Koen Yoshishu (2001) > (E)/(Z)-.ALPHA.-Trifluoromethyl-.ALPHA.,.BETA.-Unsaturated Esters: Stereoselective Preparation and Application to the Synthesis of Trifluoromethyl-Containing Nucleosides.

(E)/(Z)-.ALPHA.-Trifluoromethyl-.ALPHA.,.BETA.-Unsaturated Esters: Stereoselective Preparation and Application to the Synthesis of Trifluoromethyl-Containing Nucleosides.

Accession number;02A0620429

Title;(E)/(Z)-.ALPHA.-Trifluoromethyl-.ALPHA.,.BETA.-Unsaturated Esters: Stereoselective Preparation and Application to the Synthesis of Trifluoromethyl-Containing Nucleosides.

Author; QING F-L (Shanghai Inst. Organic Chemistry, Chinese Acad. Sci., Shanghai, Chn)

Journal Title;Fusso Kagaku Toronkai Koen Yoshishu

Journal Code:F0135B

ISSN:

VOL.25th;NO.;PAGE.79-80(2001)

Figure&Table&Reference;

Pub. Country;Japan

Language;English

Abstract;.ALPHA.-Trifluoromethyl-.ALPHA.,.BETA.-unsaturated esters (1) have served as building blocks for the preparation of trifluoromethylated biological active compounds. We developed a new method for the stereoselective preparation of (E)/(Z)-esters (1). The new route to esters (1) was based on the trifluoromethylation of .ALPHA.-bromo-.ALPHA.,.BETA.-unsaturated esters. We have applied esters (1) for the synthesis of 2',3'-dideoxy-2'-trifluoromethylnucleosides and L-2',3'-dideoxy-2'-trifluoromethyl-4'-thionucleosides. (author abst.)

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