Pathophysiology of Cerebral Infarction.
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Accession number;02A0514988
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| Title;Pathophysiology of Cerebral Infarction. |
| Author;
TANAKA KOTARO
(Keiodai I Shinkeinaika)
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Journal Title;Prog Med
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Journal Code:F0664B
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ISSN:0287-3648
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VOL.22;NO.5;PAGE.1111-1119(2002)
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| Figure&Table&Reference;FIG.6, REF.33 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Since white matter occupies a large part of human brain, white matter, not gray matter, is the central lesion in most of the patients with cerebral infarction. Basic mechanisms of ischemic injury in white matter, which mainly consists of axon, myelin and oligodendrocytes, are very different from those in gray matter, which mainly consists of soma and dendrites of neurons. White matter is very susceptible to water influx to axon at node of Ranvier, oxidative stress and microcirculatory disturbance, whereas glutamate and calcium ion may be important for injury of gray matter. Pathophysiological mechanisms of white matter injury should be elucidated in more detail to develop the efficient strategy of stroke treatment. (author abst.) |
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