Asymmetric Synthesis of .BETA.-Hydroxy-.BETA.-trihalomethyl Ketones Using Optically Active Imines of Enamines.
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Accession number;02A0620410
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| Title;Asymmetric Synthesis of .BETA.-Hydroxy-.BETA.-trihalomethyl Ketones Using Optically Active Imines of Enamines. |
| Author;
FUNABIKI KAZUMASA
(Gifu Univ., Faculty of Engineering, JPN)
HASHIMOTO WATARU
(Gifu Univ., Faculty of Engineering, JPN)
HONMA NORIHIRO
(Gifu Univ., Faculty of Engineering, JPN)
SHIBATA KATSUYOSHI
(Gifu Univ., Faculty of Engineering, JPN)
MATSUI MASAKI
(Gifu Univ., Faculty of Engineering, JPN)
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Journal Title;Fusso Kagaku Toronkai Koen Yoshishu
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Journal Code:F0135B
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ISSN:
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VOL.25th;NO.;PAGE.27-29(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The reaction of trifluoroacetaldehyde ethyl hemiacetal with chiral imines or enamines, derived from various methyl ketones and chiral amines, in the absence of additives provides the corresponding .BETA.-hydroxy-.BETA.-trifluoromethyl ketones in good yields with good enantioselectivity. The reaction of chloral in place of trifluoroacetaldehyde ethyl hemiacetal as a starting material with chiral imines under the similar conditions provides the corresponding .BETA.-hydroxy-.BETA.-trichloromethyl ketones in good yields with good enantioselectivity. (author abst.) |
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