Effective Syntheses of Fluorinated Carbinols and Amines by Use of the Germyl Anion Species.
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Accession number;02A0620417
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| Title;Effective Syntheses of Fluorinated Carbinols and Amines by Use of the Germyl Anion Species. |
| Author;
YOKOYAMA YASUO
(Sophia Univ., Fac. of Sci. and Technol.)
KOBAYASHI TAKESHI
(Sophia Univ., Fac. of Sci. and Technol.)
KAJITANI MASATSUGU
(Sophia Univ., Fac. of Sci. and Technol.)
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Journal Title;Fusso Kagaku Toronkai Koen Yoshishu
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Journal Code:F0135B
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ISSN:
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VOL.25th;NO.;PAGE.48-50(2001)
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| Figure&Table&Reference; |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Recently, the development of the effective synthesis of fluorinated compounds has attracted the attention of organo-synthetic chemists, because these products have unique biological, chemical, and physical properties. Particularly, the preparation of fluorinated carbonyl compounds is recognized as a very significant methodology, and several synthetic reaction has been reported. On the other hand, effective syntheses of 2-fluoro-2-methylalkanamide derivatives through the formation of fluorinated enolate have not been reported. Therefore, investigation of this method is important in the field of organic synthesis. In this regard, we developed the effective formation of the fluorinated enolate anion species from 2-fluoro-2-phenylthiopropionamide by use of Et3GeNa. This active species reacted with various electrophiles to give the corresponding fluorinated carbinols and amines effectively. (author abst.) |
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