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Accession number;02A0650989
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| Title;Culture Filtrate of Aspergillus fumigatus and its Cytotoxic Activity Against Leukocytes. |
| Author;
KAMEI KATSUHIKO
(Chiba Univ., Res. Center for Pathologic Fungi and Microbial Toxicoses., JPN)
WATANABE AKIRA
(Chibadai Kareibyotaigaku Kokyukinaika)
NISHIMURA KAZUKO
(Chiba Univ., Res. Center for Pathologic Fungi and Microbial Toxicoses., JPN)
MIYAJI MAKOTO
(Chiba Univ., Res. Center for Pathologic Fungi and Microbial Toxicoses., JPN)
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Journal Title;Japanese Journal of Medical Mycology
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Journal Code:G0589A
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ISSN:0916-4804
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VOL.43;NO.3;PAGE.163-166(2002)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Aspergillosis has become the biggest cause of death among mycoses in Japan. The main causative agent is Aspergillus fumigatus and its virulence factors have been variously investigated, yet much remains to be clarified. We recently found that the culture filtrate of A. fumigatus has potent anti-leukocyte activity. It seriously damages macrophages and hampers the function of polymorphonuclear neutrophils. The filtrate is also active in vivo: when injected intraperitoneally, the culture filtrate lowered the survival of mice infected with A. fumigatus. This activity becomes overt within 24 hours of culture of the fungus. Although the mechanism of pathogenicity of A. fumigatus is believed to be somewhat complex, we suggest the activities shown in the culture filtrate may play a crucial role in the development of the infection. (author abst.) |
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