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Accession number;02A0747069
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| Title;Human immunodeficiency virus (HIV) type 1 Tat binding protein-1 (TBP-1) functions as the transcription activation factor of thyroid hormone receptor |
| Author;
SATO TETSURO
(Gunma Univ., Sch. of Med.)
ISHIZUKA TAKAHIRO
(Univ. Pennsylvania, Usa)
TOMARU TAKUYA
(Gunma Univ., Sch. of Med.)
MONDEN GO
(Gunma Univ., Sch. of Med.)
YAMADA MASANOBU
(Gunma Univ., Sch. of Med.)
MORI MASATOMO
(Gunma Univ., Sch. of Med.)
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Journal Title;Clinical Endocrinology
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Journal Code:Z0648A
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ISSN:0045-7167
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VOL.50;NO.;PAGE.67-73(2002)
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| Figure&Table&Reference;FIG.7, REF.5 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;In order to analyze furthermore the role of the DNA binding domain (DBD) binding factor of nuclear hormone receptor (NR) in the ligand dependent transcription activation, new cloning of the transcription coupling factor of TR was tried by the yeast two hybrid (YTH) method using DBD of thyroid hormone receptor (TR) and part of the hinge region as the bait. From the result, it has become clear that the endogenous transcription activation domain exists in TBP-1, and it is indicated that the ATPase activity of TBP-1 is important for the reinforcement of ligand dependent transcription activation. |
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