Science Links Japan | An Autopsied Case with a Bicuspid Aortic Valve Who Had Progressive Angina Pectoris and Heart Failure during Follow-up of 27 Years.

An Autopsied Case with a Bicuspid Aortic Valve Who Had Progressive Angina Pectoris and Heart Failure during Follow-up of 27 Years.

Accession number;02A0669801

Title;An Autopsied Case with a Bicuspid Aortic Valve Who Had Progressive Angina Pectoris and Heart Failure during Follow-up of 27 Years.

Author; YOKOYAMA SATOSHI (Inst. for Adult Dis. Asahi Life Found.) ASHIDA TERUNAO (Inst. for Adult Dis. Asahi Life Found.) SUGIYAMA TAKAO (Inst. for Adult Dis. Asahi Life Found.) EBIHARA AYA (Inst. for Adult Dis. Asahi Life Found.) FUJII JUN (Inst. for Adult Dis. Asahi Life Found.) CHIDA KOJI (Tokyo Metrop, Geriatr. Hosp.) EZAKI YUKIYOSHI (Tokyo Metrop, Geriatr. Hosp.) OKAWA SHIN'ICHIRO (Tokyo Women's Medical College, Second Hospital)

Journal Title;Japanese Journal of Geriatrics

Journal Code:Z0680A

ISSN:0300-9173

VOL.39;NO.4;PAGE.444-447(2002)

Figure&Table&Reference;FIG.5, REF.7

Pub. Country;Japan

Language;Japanese

Abstract;A Japanese man who died at age 85 had been followed since the age of 59, when he first presented. He had hypertension of 162/102 mmHg and a loud systolic murmur on his first visit. He had had an active daily life without any medication for the next 10 years. At the age of 72 he complained of mild chest discomfort on exercise. Although electrocardiography showed no abnormalities, echocardiogram showed calcified bicuspid aortic valve with mild stenosis. At the age of 81 the dyspnea and chest oppression were exacerbated, associated with marked ST depression on exercise electrocardiogram and restriction of aortic valve opening on echocardiograms. In the following years a gradual increase in QRS voltage and ST depression with T wave inversion were recorded on resting electrocardiograms and sharp increases in both left ventricular enddiastolic diameter and flow velocity at the aortic root were observed on echocardiograms. At the age of 85 he died of intractable heart failure with massive pleural effusion. Autopsy revealed marked hypertrophy and moderate dilatation of the heart (weight: 580 g). The bicuspid aortic valve had anterior-posterior cusps with a raphe on the anterior cusp. The mobility of the cusps was almost lost because of severe calcification and thickening. Severe stenosis was found near the orifice of the right coronary artery, but there were no significant ischemic myocardial lesions. (author abst.)

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