Sairei-to enhances the antinephrotic effect of cyclosporine A in puromycin aminonucleoside-treated rats.
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Accession number;02A0774020
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| Title;Sairei-to enhances the antinephrotic effect of cyclosporine A in puromycin aminonucleoside-treated rats. |
| Author;
FUJITSUKA N
(Tsumura & Co., Ibaraki, Jpn)
TADA K
(Tsumura & Co., Ibaraki, Jpn)
GOTO K
(Tsumura & Co., Ibaraki, Jpn)
ISHIGE A
(Tsumura & Co., Ibaraki, Jpn)
SASAKI H
(Tsumura & Co., Ibaraki, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.4;PAGE.137-141(2002)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Sairei-to (TJ-114), a traditional herbal medicine, has been used clinically as therapy for nephrotic syndrome. This experiment was conducted to clarify whether TJ-114 could enhance the antinephrotic effect of cyclosporine A (CyA). Nephrosis was induced in rats by a single intravenous injection of puromycin aminonucleoside (PAN). TJ-114 and CyA were orally administered consecutively to the nephrotic rats. In PAN-treated rats, urinary protein excretion and levels of cholesterol and triglyceride in serum were increased, whereas the serum albumin level was decreased. Treatment with CyA dose-dependently attenuated these changes, and TJ-114 also inhibited the induction of nephrosis in the PAN-treated rats. Furthermore, it has been demonstrated that the concomitant use of TJ-114 with CyA enhanced the antinephrotic effect at a dose of CyA 10mg/kg, and conversely inhibited the increase in serum creatinine at a dose of CyA 40mg/kg in nephrotic rats. These findings suggested that TJ-114 may be useful for lowering the therapeutic dose of CyA in nephrotic syndrome. (author abst.) |
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