Effect of a hot water extract of Agaricus blazei fruiting bodies(CJ-01) on the intracellular cytokines level in a patient with bronchitis.

Accession number;02A0774021
Title;Effect of a hot water extract of Agaricus blazei fruiting bodies(CJ-01) on the intracellular cytokines level in a patient with bronchitis.
Author; MIYAMOTO K (Yamaguchi Univ. School Of Medicine, Yamaguchi, Jpn) WATANABE Y (Tokyo Medical Univ., Tokyo, Jpn) IIZUKA N (Yamaguchi Univ. School Of Medicine, Yamaguchi, Jpn) SAKAGUCHI E (Yamaguchi Univ. School Of Medicine, Yamaguchi, Jpn) OKITA K (Yamaguchi Univ. School Of Medicine, Yamaguchi, Jpn)
Journal Title;Journal of Traditional Medicines
Journal Code:Y0941A
ISSN:1340-6302
VOL.19;NO.4;PAGE.142-147(2002)
Figure&Table&Reference;FIG.2, TBL.2, REF.23
Pub. Country;Japan
Language;English
Abstract;Effect of an oral intake of a hot water extract of Agaricus blazei (CJ-01) on the levels of intracellular cytokines was examined in a bronchitic patient with asthma like attacks. The patient showed an improvement of the symptoms such as frequent cough and sputum after 2 months oral intake of CJ-01. We measured the intracellular production of IL-2 and interferon gamma (IFN-.GAMMA.), pro-inflammatory Th1 cytokines, as well as IL-10, anti-inflammatory Th2 cytokine, in mitogen-stimulated peripheral blood lymphocytes. Flow cytometric analysis showed an elevation of intracellular IFN-.GAMMA. level in the lymphocytes of the patient. A deterioration of the symptoms of the patient was observed 3 months after discontinuance of CJ-01. A reduction of IFN-.GAMMA. level was also observed in parallel. However, resuming oral intake of CJ-01 showed again an ameliolation of the symptoms and the elevation of IFN-.GAMMA. level was repeatedly observed. The patient further acquired a resistance to catching colds. These results suggest that the immune enhancing effect of CJ-01 may improve the symptoms of bronchitis through a promotion of pro-inflammatory cytokine production. (author abst.)
Related Articles;
Loading...