Science Links Japan | Influence of Switching from ACE Inhibitor (enalapril) to Angiotensin II Receptor Blocker (candesartan) on Antihypertensive effect and Diurnal Variation in Blood Pressure in Patients with Essential Hypertension. A Study Using ABPM.

Influence of Switching from ACE Inhibitor (enalapril) to Angiotensin II Receptor Blocker (candesartan) on Antihypertensive effect and Diurnal Variation in Blood Pressure in Patients with Essential Hypertension. A Study Using ABPM.

Accession number;02A0862852

Title;Influence of Switching from ACE Inhibitor (enalapril) to Angiotensin II Receptor Blocker (candesartan) on Antihypertensive effect and Diurnal Variation in Blood Pressure in Patients with Essential Hypertension. A Study Using ABPM.

Author; NAKAJIMA HITOSHI (Tokyo Medical Univ., JPN) HARA TAKESHI (Tokyo Medical Univ., JPN) HIRAYAMA YOJI (Tokyo Medical Univ., JPN) YAMASHINA AKIRA (Tokyo Medical Univ., JPN)

Journal Title;Journal of Clinical Therapeutics & Medicines

Journal Code:Y0906A

ISSN:0910-8211

VOL.18;NO.9;PAGE.1077-1085(2002)

Figure&Table&Reference;FIG.6, TBL.2, REF.13

Pub. Country;Japan

Language;Japanese

Abstract;Ambulatory blood pressure monitoring (ABPM) was undertaken in order to evalute changes in the antihypertensive efficacy and its duration following the switchover from the ACE inhibitor enalapril to the Angiotensin II receptor blocker (ARB) candesartan. The subjects were outpatients with essential hypertension in Tokyo Medical University Hospital. Eleven patients, who had been given enalapril at a daily dose of 5-10 mg for 8 weeks or longer until a stable antihypertensive effect was confirmed by monitoring the causal blood pressure, had their medication switched to candesartan at a daily dose of 8-12 mg for 8 additional weeks. Ambulatory blood pressure was monitored for 24 hours before and 8 weeks after the exchange to candesartan, and a significant decrease was confirmed in average systolic blood pressure. In an evaluation of blood pressure divided into 3 time periods, significant decreases were confirmed in systolic blood pressure in the daytime (8:00 to 21:00) and in systolic and diastolic blood pressure in the early morning (5:00 to 8:00). In a comparison of the elevation of blood pressure before and after rising, blood pressure after rising was significantly decreased after switching from enalapril to candesartan. It was suggested that candesartan has an excellent and long-acting antihypertensive effect, and that after direct exchange from enalapril, candesartan controls blood pressure more effectively. The subjects were outpatients with essential hypertension in Tokyo Medical College Hospital. Eleven patients, who had been given enalapril at a daily dose of 5-10 mg for 8 weeks or longer until a stable antihypertensive effect was confirmed by monitoring the causal blood pressure, had their medication switched to candesartan at a daily dose of 8-12 mg for 8 additional weeks.... (author abst.)

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