Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus.
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Accession number;02A0904520
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| Title;Inhibitory activities of Thai medicinal plants against herpes simplex type 1, poliovirus type 1, and measles virus. |
| Author;
AKANITAPICHAT P
(Ubon Ratchathani Univ., Ubon Ratchathani, Tha)
KUROKAWA M
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
TEWTRAKUL S
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
PRAMYOTHIN P
(Chulalongkorn Univ., Bangkok, Tha)
SRIPANIDKULCHAI B
(Khonkaen Univ., Khonkaen, Tha)
SHIRAKI K
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
HATTORI M
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.5;PAGE.174-180(2002)
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| Figure&Table&Reference;TBL.1, REF.17 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Forty-eight ethanol- and 43 water-extracts of 49 traditional Thai medicines were evaluated for antiviral activities by a plaque reduction assay. For preliminary characterization of the mode of their antiviral action, poliovirus type 1, measles virus and herpes simplex virus type 1(HSV-1) that are different in nucleic acid component and enveloped structure were used in this study. Fifty-two, 28 and 29 extracts exhibited inhibitory activities against poliovirus, measles virus and HSV-1, respectively. Of 29 extracts with anti-HSV-1 activities, the inhibitory activities of Rhinacanthus nasutus (leaf), Terminalia citrina (fruit) and Thevetia peruviana (leaf) were observed in both ethanol and water extracts. The ethanol extracts of Derris scandens (leaf) and Plumbago indica (leaf) and the water extract of Capsicum frutescens (fruit) were active against only HSV-1, suggesting the mechanism of their antiviral action likely unique to HSV-1 but neither poliovirus nor measles virus. Contrarily, 26 extracts displayed inhibitory activities against poliovirus and/or measles virus. These findings suggest that the 29 extracts from traditional Thai medicines are potential candidates for anti-HSV agents. (author abst.) |
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