The Anxiolytic-like Effect of Ginkgo Biloba Extract and the Constituents Assessed by an Improved Plus-maze Test in Mice.
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Accession number;03A0015804
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| Title;The Anxiolytic-like Effect of Ginkgo Biloba Extract and the Constituents Assessed by an Improved Plus-maze Test in Mice. |
| Author;
KURIBARA HISASHI
(Gunmadai Chiikikyodokense)
YOSHIHAMA TATSUMI
(Wakokagaku Kenkyukaihatsubu)
MARUYAMA YUJI
(Gunmadai Chiikikyodokense)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.11;PAGE.955-962(2002)
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| Figure&Table&Reference;TBL.4, REF.39 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The anxiolytic-like effect of ginkgo biloba extract (GBE) and its four ginkgo-terpenoids (ginkgolide-A, ginkgolide-B, ginkgolide-C, and bilobalide) were assessed by an improved plus-maze test in mice. The single oral administration of GBE (0.5 and 1g/kg) shortened the time spent in the open arms with suppression of the motor activity. However, when GBE (0.063-1g/kg p.o.) was administered daily for seven days and the plus-maze test was carried out 24 hr after the last administration, prolongation of the time spent in the open arms was developed with the peak effect at 0.13g/kg, showing an anxiolytic-like effect. Diazepam, following the single oral administration at 1mg/kg, also prolonged the time spent in the open arms. The combination of the seven daily administration of GBE (0.13g/kg) and single administration of diazepam (1mg/kg) enhanced the anxiolytic-like effect. Flumazenil (0.3mg/kg i.p.) blocked the effect of diazepam, but not of GBE. Among the ginkgo-terpenoids, the daily administration of ginkgolide-A (1 and 2mg/kg p.o.) developed the anxiolytic-like effect by the 3rd administration, and the effect achieved to the highest plateau level by the 5th administration. Whereas, the seven daily treatment with ginkgolide-B (1mg/kg), ginkgolide-C (1mg/kg) or bilobalide (1 and 2mg/kg) caused no anxiolytic-like effect. These results suggest that GBE produces significant anxiolytic-like effect following the repeated administration, and that ginkgolide-A is responsible for this effect. However, it is unlike that benzodiazepine receptors are involved in the development of the anxiolytic-like effect of GBE and ginkgolide-A. (author abst.) |
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