Synthesis and DNA Strand Breakage Activity of Some 1,4-Diazepines.
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Accession number;03A0040953
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| Title;Synthesis and DNA Strand Breakage Activity of Some 1,4-Diazepines. |
| Author;
MIBU N
(Fukuoka Univ., Fukuoka, Jpn)
YUKAWA M
(Fukuoka Univ., Fukuoka, Jpn)
KASHIGE N
(Fukuoka Univ., Fukuoka, Jpn)
IWASE Y
(Fukuoka Univ., Fukuoka, Jpn)
GOTO Y
(Fukuoka Univ., Fukuoka, Jpn)
MIAKE F
(Fukuoka Univ., Fukuoka, Jpn)
YAMAGUCHI T
(Miyazaki Medical Coll., Miyazaki, Jpn)
ITO S
(Tokyo Medical And Dental Univ., Tokyo, Jpn)
SUMOTO K
(Fukuoka Univ., Fukuoka, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.1;PAGE.27-31(2003)
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| Figure&Table&Reference;TBL.4, REF.15 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Reactions of 1,3-propanediamine with .ALPHA.-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity. (author abst.) |
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