Norlanostane and Lanostane Glycosides from the Bulbs of Chionodoxa luciliae and Their Cytotoxic Activity.
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Accession number;03A0040965
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| Title;Norlanostane and Lanostane Glycosides from the Bulbs of Chionodoxa luciliae and Their Cytotoxic Activity. |
| Author;
ORI K
(Tokyo Univ. Pharmacy And Life Sci., Tokyo, Japan)
KURODA M
(Tokyo Univ. Pharmacy And Life Sci., Tokyo, Japan)
MIMAKI Y
(Tokyo Univ. Pharmacy And Life Sci., Tokyo, Japan)
SAKAGAMI H
(Meikai Univ. School Of Dentistry, Saitama, Jpn)
SASHIDA Y
(Tokyo Univ. Pharmacy And Life Sci., Tokyo, Japan)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.1;PAGE.92-95(2003)
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| Figure&Table&Reference;TBL.2, REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Ten lanostane glycosides (1-10), including two new norlanostane glycosides (2 and 7) and a new lanostane glycoside with a spirolactone ring system (9), were isolated from the fresh bulbs of Chionodoxa luciliae (Liliaceae). The structures of the new compounds were determined on the basis of extensive spectroscopic analysis and the results of hydrolytic cleavage to be (23S)-3.BETA.-[(O-.BETA.-D-apiofuranosyl-(1.RAR.2)-O-[.BETA.-D-glucopyranosyl-(1.RAR.3)]-O-.BETA.-D-glucopyranosyl-(1.RAR.2)-.ALPHA.-L-arabinopyranosyl-(1.RAR.6)-.BETA.-D-glucopyranosyl)oxy]-17.ALPHA.,23-epoxy-28,29-dihydroxy-27-norlanost-8-en-24-one (2), (23S)-17.ALPHA.,23-epoxy-29-hydroxy-3.BETA.-[(O-.ALPHA.-L-rhamnopyranosyl-(1.RAR.2)-O-[O-.BETA.-D-glucopyranosyl-(1.RAR.2)-.BETA.-D-glucopyranosyl-(1.RAR.3)]-O-.BETA.-D-glucopyranosyl-(1.RAR.2)-.ALPHA.-L-arabinopyranosyl-(1.RAR.6)-.BETA.-D-glucopyranosyl)oxy]-27-norlanost-8-ene-15,24-dione (7), and (23S,25R)-17.ALPHA.,23-epoxy-29-hydroxy-3.BETA.-[(O-.ALPHA.-L-rhamnopyranosyl-(1.RAR.2)-O-[.BETA.-D-glucopyranosyl-(1.RAR.3)]-O-.BETA.-D-glucopyranosyl-(1.RAR.2)-.ALPHA.-L-arabinopyranosyl-(1.RAR.6)-.BETA.-D-glucopyranosyl)oxy]lanost-8-en-23,26-olide (9), respectively. The cytotoxic activity of the isolated compounds against HSC-2 human oral squamous cell carcinoma cells are also reported. (author abst.) |
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