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Accession number;03A0040613
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| Title;Molecular switch for mRNA synthesis rate. |
| Author;
WADA TADASHI
(Tokyo Inst. of Technol.)
YAMAGUCHI YUKI
(Tokyo Inst. of Technol.)
HANDA HIROSHI
(Tokyo Inst. Technol., Frontier Collaborative Res. Center, JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.1;PAGE.9-17(2003)
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| Figure&Table&Reference;FIG.4, REF.35 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The first step reaction of the central dogma where RNA is transcribed from DNA is the main control step of gene expression. Authors have succeeded in identifying DSIF and NELF as protein factors to control transcription rates. DSIF controls RNA chain elongation stage in transcription reaction by directly binding to RNA polymerase II. As DSIF accelerates or suspends the elongation reaction according to conditions, it is considered to have roles of both an accelerator and a suppressor for transcription. NELF binds to DSIF-RNAPII complex, and induces temporary suspension of elongation. In differentiation stage of vertebrates' nerve cells, abnormalities are observed because of extinction of DSIF's brake activity in differentiation directions. In the meantime, delta antigens which antagonize NELF, are encoded in D-type hepatitis virus gene causing serious hepatic diseases. Therefore, intracellular control of NFLF activity is closely involved in virus multiplication and canceration of hepatocytes. This article reviews molecular switch for mRNA synthesis rate consisting of DSIF and NELF. |
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