Crystal structure of bacterial multidrug efflux transporter AcrB.
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Accession number;03A0040615
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| Title;Crystal structure of bacterial multidrug efflux transporter AcrB. |
| Author;
MURAKAMI SATOSHI
(Osaka Univ., Inst. Sci. and Ind. Res., JPN)
YAMAGUCHI AKIHITO
(Osaka Univ., Inst. Sci. and Ind. Res., JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.1;PAGE.26-32(2003)
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| Figure&Table&Reference;FIG.7, REF.26 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Crystal structure of bacterial multidrug efflux transporter AcrB from Escherichia coli was obtained at 3.5.ANGS. resolution. This is the first proton conjugated transformer which has ever determined its crystal structure among others. AcrB is a trimer composed of 3 monomers, one of which consists of 1049 amino acid residues, and has a head part protruding to 70.ANGS. periplasm and a transmembrane part with 12 transmembrane helices per monomer. Foreign substances are uptaken not only from the side of cytoplasm, but also from the entrance of lower end side of the head part which is opening to the periplasm. This article describes the foreign substances may be transported into outer membrane channel TolC, which is directly bound to AcrB, from the funnel-shaped opening at tip by opening and closing the pore in the center of the head part, after the foreign substances are collected into an empty cavity. |
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