Usefulness of Caffeine Test in Predicting Hepatic Injury Induced by Flutamide.
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Accession number;03A0059370
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| Title;Usefulness of Caffeine Test in Predicting Hepatic Injury Induced by Flutamide. |
| Author;
OZONO SEIICHIRO
(Nara Medical Univ., Medical Faculty, JPN)
YAMAGUCHI AKIRA
(Nara Medical Univ., Medical Faculty, JPN)
HIRAO YOSHIHIKO
(Nara Medical Univ., Medical Faculty, JPN)
ICHINEI MEGUMI
(Nippon Kayaku Co., Ltd.)
YAMASHITA TAKUMI
(Nippon Kayaku Co., Ltd.)
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Journal Title;Japanese Pharmacology & Therapeutics
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Journal Code:Z0947A
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ISSN:0386-3603
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VOL.30;NO.Suppl.2;PAGE.S.353-S.356(2002)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.14 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;The present investigation was conducted to examine the usefulness of the caffeine test, which measures the activity of cytochrome P450 1A2 (CYP1A2), in predicting hepatic injury induced by Flutamide in patients with prostate cancer. The subjects were divided into three groups: (1) those patients whose AST or ALT level rose to 100 IU/L or higher after the administration of Flutamide (moderately injured group); (2) those patients whose AST and ALT levels were higher than normal but less than 100 IU/L (mildly injured group); and (3) those patients whose hepatic function remained normal (normal group). The subjects were given canned coffee, and urinary caffeine (137X), paraxanthine (17X) and 1,7-dimethyluric acid (17 U) levels were measured using HPLC 4-5 hours later. The metabolite ratio, (17 U+17X)/137X, was calculated to serve as CYP1A2 activity The CYP1A2 activity for the moderately and mildly injured groups were significantly lower than that for the normal group, suggesting that a decrease in CYP1A2 activity is involved in the hepatic injury induced by Flutamide, and that the caffeine test will allow us to identify individuals who are at increased risk of this adverse event. (author abst.) |
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