Science Links Japan | The Successful Method of Replacing Human Regular Insulin with Short-acting Insulin Analog Lispro. Treatment with the Short-acting Insulin Analog Lispro in Variable Combination with NPH Insulin at Mealtime.

The Successful Method of Replacing Human Regular Insulin with Short-acting Insulin Analog Lispro. Treatment with the Short-acting Insulin Analog Lispro in Variable Combination with NPH Insulin at Mealtime.

Accession number;03A0059390

Title;The Successful Method of Replacing Human Regular Insulin with Short-acting Insulin Analog Lispro. Treatment with the Short-acting Insulin Analog Lispro in Variable Combination with NPH Insulin at Mealtime.

Author; OGAWA SUSUMU (Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka) TAKEUCHI KAZUHISA (Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka) ISHIZUKA TSUNEO (Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka) KATO TARO (Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka) OKA YOSHITOMO (Tohokudai I Byoin Tonyobyotaishaka) ITO SADAYOSHI (Tohokudai I Byoin Jinkoketsuatsunaibumpitsuka)

Journal Title;Japanese Pharmacology & Therapeutics

Journal Code:Z0947A

ISSN:0386-3603

VOL.30;NO.12;PAGE.1003-1008(2002)

Figure&Table&Reference;FIG.2, TBL.2, REF.12

Pub. Country;Japan

Language;Japanese

Abstract;Objectives: To establish the method of replacing human regular insulin (R) with short-acting insulin analog lispro (LP), and to examine the effects of the replacement on postprandial glycemic control. Methods: We examined ten diabetic patients who had been treated with intensive insulin therapy. We measured the plasma glucose levels before a 400 kcal meal, and 30-, 60-, 90-, 120-, 180-, 240- and 360-min postprandial plasma glucose levels (PPG). R, as well as various doses of LP (100%, 75%, 50% 25% of R dose) were tried before the meal. Various doses of NPH were added with LP before the meal, and the mixing percentages of LP/NPH were 75/25, 50/50, 25/75, 0/100. Results: PPG was lower in the LP + NPH combination-therapy than that in the R, NPH, LP monotherapy. The PPG was improved most successfully and hypoglycemia was less frequent with the mixing percentage 50/50 or 75/25. Conclusions: We concluded that, compared with R and other mixing percentages of LP and NPH, mealtime injection of LP and NPH combination therapies using mixing percentage of 75/25 or 50/50 results in better postprandial glucose levels with less frequent hypoglycemia as well. (author abst.)

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