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Accession number;03A0078640
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| Title;Clinical features of proliferative diabetic retinopathy as related to vitreous level of vascular endothelial growth factor (VEGF). |
| Author;
YOKOI MASAHIKO
(Hokudai Daigakuin'igakukenkyuka Shikakukibyogakubun'ya)
OGAMI KAZUHIRO
(Hokudai Daigakuin'igakukenkyuka Shikakukibyogakubun'ya)
WATANABE KAZUNORI
(Hokudai Daigakuin'igakukenkyuka Shikakukibyogakubun'ya)
ONO SHIGEAKI
(Hokudai Daigakuin'igakukenkyuka Shikakukibyogakubun'ya)
FURUDATE NAOKI
(Keijinkai Teine Keijinkai Hospital, JPN)
KASE MANABU
(Keijinkai Teine Keijinkai Hospital, JPN)
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Journal Title;Japanese Journal of Clinical Ophthalmology
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Journal Code:Z0515B
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ISSN:0370-5579
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VOL.57;NO.1;PAGE.41-45(2003)
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| Figure&Table&Reference;FIG.4, REF.11 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;We quantitated the intravitreal level of vascular endothelial growth factor (VEGF) in 24 eyes of proliferative diabetic retinopathy from samples obtained during vitrectomy. Out of the 24 eyes, 11 had received no photocoagulation prior to surgery and 13 eyes had received panretinal photocoagulation. The intravitreal level of VEGF averaged 2,707.+-.1,171pg/ml in the former group and 903.+-.584pg/ml in the latter. The difference was significant (p<0.01). The VEGF level was independent on the presence of retinal detachment or proliferative membrane. It was elevated when vitreous hemorrhage was present in eyes with no past history of photocoatulation (p<0.05). It was independent on vitreous hemorrhage in eyes with prior photo-coagulation. It seemed likely that the intravitreal level of VEGF was positively correlated with retinal neovascularization and rubeosis of the iris or chamber angle. (author abst.) |
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