Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells.
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Accession number;03A0096287
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| Title;Synthesis of Potent and Selective Inhibitors against the Proliferation of Human Coronary Artery Smooth Muscle Cells. |
| Author;
OGITA H
(Japan Energy Corp., Saitama, Jpn)
ISOBE Y
(Japan Energy Corp., Saitama, Jpn)
TAKAKU H
(Japan Energy Corp., Saitama, Jpn)
SEKINE R
(Japan Energy Corp., Saitama, Jpn)
GOTO Y
(Japan Energy Corp., Saitama, Jpn)
MISAWA S
(Japan Energy Corp., Saitama, Jpn)
HAYASHI H
(Japan Energy Corp., Saitama, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.117-121(2003)
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| Figure&Table&Reference;TBL.2, REF.13 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A series of diarylamide urea derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2h was much superior to Tranilast, in terms of both the potency of its inhibitory activity toward the proliferation of SMCs and the cell selectivity. (author abst.) |
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