Effects of Natural Polysaccharide Addition on Drug Release from Calcium-Induced Alginate Gel Beads.
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Accession number;03A0096306
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| Title;Effects of Natural Polysaccharide Addition on Drug Release from Calcium-Induced Alginate Gel Beads. |
| Author;
MURATA Y
(Hokuriku Univ., Kanazawa, Jpn)
TSUMOTO K
(Hokuriku Univ., Kanazawa, Jpn)
KOFUJI K
(Hokuriku Univ., Kanazawa, Jpn)
KAWASHIMA S
(Hokuriku Univ., Kanazawa, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.218-220(2003)
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| Figure&Table&Reference;FIG.4, REF.12 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Calcium-induced alginate gel beads (Alg-Ca) containing various polysaccharides, including an alginate hydrolysate, were prepared and the drug release profiles were investigated. Hydrocortisone (HC) was gradually released from Alg-Ca into the mimic gastric fluid, while in intestinal fluid, it was quickly released with the dissolution of Alg-Ca. However, with Alg-Ca containing 5% chitin (CT), dissolution of Alg-Ca was not observed, and release of HC showed apparent zero-order kinetics. Furthermore, addition of the alginate hydrolysate altered the HC-release profile for Alg-Ca. (author abst.) |
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