Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(.ALPHA.,.ALPHA.-diphenyl-2-pyrrolidinemethanol) Carbonate.
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Accession number;03A0096307
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| Title;Asymmetric Borane Reduction of Prochiral Ketone Using Chiral Bis(.ALPHA.,.ALPHA.-diphenyl-2-pyrrolidinemethanol) Carbonate. |
| Author;
YANAGI T
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
KIKUCHI K
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
TAKEUCHI H
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
ISHIKAWA T
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
NISHIMURA T
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
KUBOTA M
(Kissei Pharmaceutical Co., Ltd., Nagano, Jpn)
YAMAMOTO I
(Shinshu Univ., Nagano, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.221-223(2003)
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| Figure&Table&Reference;FIG.1, TBL.2, REF.10 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Chiral bis(.ALPHA.,.ALPHA.-diphenyl-2-pyrrolidinemethanol) carbonate (DPP2 H2CO3) is a useful asymmetric auxiliary for the asymmetric borane reduction of prochiral ketones. Chiral DPP2 H2CO3 is recoverable from the reaction and directly reusable for the reaction. The intermediate of KUR-1246, which we are developing as a new uterine relaxant, was synthesized using the methodology. (author abst.) |
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