Steric-Control for the Enantioselective Hydrolysis of Amino Acid Esters in Hybrid Membrane Systems.
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Accession number;03A0096308
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| Title;Steric-Control for the Enantioselective Hydrolysis of Amino Acid Esters in Hybrid Membrane Systems. |
| Author;
TANOUE O
(Sojo Univ., Kumamoto, Jpn)
ICHIHARA H
(Sojo Univ., Kumamoto, Jpn)
GOTO K
(Sojo Univ., Kumamoto, Jpn)
MATSUMOTO Y
(Sojo Univ., Kumamoto, Jpn)
UEOKA R
(Sojo Univ., Kumamoto, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.224-226(2003)
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| Figure&Table&Reference;FIG.4, REF.15 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The enantioselective hydrolysis of the amino acid esters, p-nitrophenyl-N-dodecanoyl-D(L)-phenylalaninates (C12-D(L)-Phe-PNP) catalyzed by active tripeptide, N-(benzyloxycarbonyl)-L-phenylalanyl-L-histidyl-L-leucine (Z-PheHisLeu) in the presence of coaggregates (hybrid membranes) composed of native phospholipid, L-.ALPHA.-dimyristoylphosphatidylcholine (DMPC) and nonionic surfactant, polyoxyethylene (8) lauryl ether (C12(EO)8) was easily controlled by regulating the reaction temperature and changing the composition of coaggregates. Furthermore, excellent correlations were observed between the enantioselectivity in the hydrolysis of C12-D(L)-Phe-PNP catalyzed by Z-PheHisLeu in the presence of coaggregates and physical properties of hybrid membranes. It is assumed that catalytic activities of tripeptide catalyst in hybrid membranes should be regulated by changing the microenvironments of reaction fields. (author abst.) |
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