Novel Channel Structure of Bile Acid-Guest Inclusion Complex Formed between Ursodeoxycholic Acid and Phenanthrene.
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Accession number;03A0096309
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| Title;Novel Channel Structure of Bile Acid-Guest Inclusion Complex Formed between Ursodeoxycholic Acid and Phenanthrene. |
| Author;
FUKAMI T
(Chiba Univ., Chiba, Jpn)
YAMAGUCHI K
(Chiba Univ., Chiba, Jpn)
TOZUKA Y
(Chiba Univ., Chiba, Jpn)
MORIBE K
(Chiba Univ., Chiba, Jpn)
OGUCHI T
(Univ. Yamanashi, Yamanashi, Jpn)
YAMAMOTO K
(Chiba Univ., Chiba, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.227-229(2003)
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| Figure&Table&Reference;FIG.4, TBL.1, REF.16 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The crystal structure of inclusion complex between ursodeoxycholic acid (UDCA), and phenanthrene has been determined. UDCA molecules formed hydrogen bond network to provide the channel structure along b axis, and phenanthrene molecules were accommodated in the cavity with a stoichiometry of 1 : 1 molar ratio. The channel structure observed in the UDCA-phenanthrene complex was significantly different from that of inclusion complex previously reported for deoxycholic acid (DCA) and cholic acid (CA). Because of the mesh-like hydrogen bond network, channel framework of UDCA could have less flexibility than that of DCA and CA. The difference of molecular state of phenanthrene was clearly observed in solid-state fluorescence measurement. (author abst.) |
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