Anti-diabetes Effect of Zn(II)/Carnitine Complex by Oral Administration.
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Accession number;03A0096310
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| Title;Anti-diabetes Effect of Zn(II)/Carnitine Complex by Oral Administration. |
| Author;
YOSHIKAWA Y
(Osaka City Univ., Osaka, Jpn)
UEDA E
(Osaka City Univ., Osaka, Jpn)
SAKURAI H
(Kyoto Pharmaceutical Univ., Kyoto, Jpn)
KOJIMA Y
(Osaka City Univ., Osaka, Jpn)
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Journal Title;Chem Pharm Bull
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Journal Code:G0504A
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ISSN:0009-2363
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VOL.51;NO.2;PAGE.230-231(2003)
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| Figure&Table&Reference;FIG.4, REF.20 |
| Pub. Country;Japan |
| Language;English |
| Abstract;A novel bis(L-carnitinato)Zn(II) complex, Zn(car)2Cl2, was prepared, and its insulinomimetic and antidiabetic activities were examined. The complex showed a tendency to lower the high blood glucose levels of KK-Ay mice with type 2 diabetes mellitus when given by oral administration at a dose of 20 mg Zn/kg body weight for 16 d. In addition, the complex improved glucose tolerance ability when examined by the oral glucose tolerance test (1 g glucose/kg body weight). (author abst.) |
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