Appearance of T Cell Subpopulations in the Chicken and Embryo Retina.
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Accession number;03A0101994
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| Title;Appearance of T Cell Subpopulations in the Chicken and Embryo Retina. |
| Author;
IMAGAWA T
(Tottori Univ., Tottori, Jpn)
KITAGAWA H
(Kobe Univ., Kobe, Jpn)
UEHARA M
(Tottori Univ., Tottori, Jpn)
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Journal Title;J Vet Med Sci
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Journal Code:F0905A
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ISSN:0916-7250
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VOL.65;NO.1;PAGE.23-28(2003)
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| Figure&Table&Reference;FIG.6, TBL.1, REF.32 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Under pathological conditions such as autoimmune encephalomyelitis or autoimmune uveoretinitis, many T cells infiltrate the central nervous system (CNS) and retina. Even in normal condition, a small number of T cells are detected in the CNS. However the characteristics of the T cells are not defined. To investigate the T cell characteristics in a healthy retina, the chicken and the embryo were observed by morphological and immunohistochemical methods. In the chicken retina, T cells were regularly detected, and the main subset was CD-8+/.GAMMA..DELTA. cells. Developmentally. CD positive cells appeared on embryonic day 13, and the constituent T cell repertoires became the same as in the chicken by embryonic day 17. Many T cell repertoires were detected on embryonic day 15 and 16. The present results confirm that the retina receives an immunological surveillance by T cells. The composition of T cells in retina is constructed after embryonic day 17. Many ganglion cells die in embryonic days 15 and 16. So the T cell subsets in these periods may involve in autoimmune diseases. (author abst.) |
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