Effects of Salivary Gland Extract from Rhipicephalus sanguineus on IgG Subclass Production and Cytokine mRNA Expression in Mononuclear Cells of Canine Peripheral Blood.
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Accession number;03A0102015
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| Title;Effects of Salivary Gland Extract from Rhipicephalus sanguineus on IgG Subclass Production and Cytokine mRNA Expression in Mononuclear Cells of Canine Peripheral Blood. |
| Author;
MATSUMOTO K
(Yamaguchi Univ., Yamaguchi, Jpn)
INOKUMA H
(Yamaguchi Univ., Yamaguchi, Jpn)
OKUDA M
(Yamaguchi Univ., Yamaguchi, Jpn)
ONISHI T
(Yamaguchi Univ., Yamaguchi, Jpn)
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Journal Title;J Vet Med Sci
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Journal Code:F0905A
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ISSN:0916-7250
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VOL.65;NO.1;PAGE.137-140(2003)
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| Figure&Table&Reference;FIG.2, REF.22 |
| Pub. Country;Japan |
| Language;English |
| Abstract;The effects of salivary gland extract (SGE) from R. sanguineus were examined on the production of IgG1 and IgG2 and the mRNA expression of IFN-.GAMMA., IL-2, IL-4, IL-5 and IL-10 in the mononuclear cells from canine peripheral blood, treated with concanavalin A (ConA) in vitro. SGE suppressed the ConA-induced production of IgG2. It also inhibited the expression of IFN-.GAMMA., IL-2 and IL-5 mRNA in a dose-dependent manner. No dose-dependent suppression was observed of IL-10 mRNA expression although a significant effect was observed at a SGE protein concentration of 25.MU.g/ml. SGE had no effect on the mRNA expression of IL-4. These results suggest that the suppression of IgG2 production by SGE from R. sanguineus was caused by the suppression of IFN-.GAMMA. production. (author abst.) |
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