Drug Concentration-Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery.
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Accession number;03A0107690
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| Title;Drug Concentration-Time Profile in the Plasma Following the Dissolution-Type Transdermal Delivery. |
| Author;
MORI D
(Kyushu Inst. Technol., Fukuoka, Jpn)
KAWAMATA H
(Kyushu Inst. Technol., Fukuoka, Jpn)
TOJO K
(Kyushu Inst. Technol., Fukuoka, Jpn)
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Journal Title;J Chem Eng Jpn
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Journal Code:S0629A
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ISSN:0021-9592
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VOL.36;NO.1;PAGE.45-48(2003)
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| Figure&Table&Reference;FIG.3, TBL.1, REF.10 |
| Pub. Country;Japan |
| Language;English |
| Abstract;In medical treatment, a constant plasma concentration for an extended period of time is preferable for some diseases, while pulsatile delivery or delayed delivery is also required to avoid the tolerance and set a delayed time for medication. The dissolution-type TTS is expected to achieve pulsatile delivery. In this work, a mathematical model was proposed for the prediction of the plasma concentration-time profile following the application of the dissolution-type TTS. In vivo animal data was compared with the simulated profile together with the model parameters determined independently. The calculated concentration-time profile well agreed with the in vivo animal data. (author abst.) |
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