Role of the nectin-afadin system in organization of tight and adherens junctions in epithelial cells.
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Accession number;03A0078704
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| Title;Role of the nectin-afadin system in organization of tight and adherens junctions in epithelial cells. |
| Author;
KATATA TATSUO
(Osaka Univ., Graduate School of Medicine, JPN)
IRIE KENJI
(Osaka Univ., Graduate School of Medicine, JPN)
TAKAI YOSHIMI
(Osaka Univ., Graduate School of Medicine, JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.2;PAGE.105-112(2003)
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| Figure&Table&Reference;FIG.4, REF.41 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Intercellular adhesion devices in epithelial cells are mainly composed of cadherin-dependent adherens junctions and claudin-dependent tight junctions. Authors have found new intercellular adhesion mechanisms composed of nectin, an adhesive molecule, and afadin, an actin filament binding protein, and are now analyzing the mechanism. They have already elucidated that in epithelial cells, nectin-afadin system localizes at adherens junctions and it plays an important role for the formation of adherens junctions and tight junctions by cooperatively interactingg with cadherin-cathenin system. The nectin-afadin system is also clarified to be involved in intracellular signal transductions such as cell polarity formation, controlling both actin cytoskeleton, and gene expression. |
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