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Accession number;03A0078706
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| Title;Polarized expression of drug transporters and its physiological significance. |
| Author;
ITO KOSEI
(Chibadai Daigakuin'yakugakukenkyuin)
SUZUKI HIROSHI
(Univ. Tokyo, Graduate School of Parmaceutical Sciences, JPN)
HORIE TOSHIHARU
(Chibadai Daigakuin'yakugakukenkyuin)
SUGIYAMA YUICHI
(Univ. Tokyo, Graduate School of Parmaceutical Sciences, JPN)
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Journal Title;Protein, Nucleic Acid and Enzyme
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Journal Code:F0325A
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ISSN:0039-9450
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VOL.48;NO.2;PAGE.122-132(2003)
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| Figure&Table&Reference;FIG.5, TBL.1, REF.30 |
| Pub. Country;Japan |
| Language;Japanese |
| Abstract;Many of drug transporters localize in either apical or basolateral sides of polar cells, and are involved in vectorian transports of substrates. Drug transporters are originally involved in absorption of materials required for bodies, and detoxication and excretion of toxic substances, and are distributed to demonstrate their functions maximally. Hepatic cells are polar cells forming most import organs which perform detoxication and excretion of drugs, and are important to consider drug disposition kinetics. Localization disorders of some transporters in hepatic cells are also known to cause hereditary diseases. This article especially introduces localization mechanism of drug transporters in liver by comparing with general localization mechanisms. |
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