Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine.
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Accession number;03A0126861
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| Title;Induction of heat shock protein (hsp 70) in human lymphocytes by Kampo herbal medicine. |
| Author;
SUZUKI M
(Univ. Tokyo, Tokyo, Jpn)
JIN G-B
(Univ. Tokyo, Tokyo, Jpn)
TOMII M
(Univ. Tokyo, Tokyo, Jpn)
OGUCHI K
(Showa Univ., Tokyo, Jpn)
CYONG J-C
(Juntendo Univ., Tokyo, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.6;PAGE.193-199(2002)
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| Figure&Table&Reference;FIG.2, TBL.1, REF.11 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Heat shock protein (hsp 70) plays an important role in normalizing proteins that have degenerated due to stress, and in maintaining the physiological functions of cells. It has been reported that the induction of hsp 70 may decline aging, and may be involved in autoimmune diseases and bacterial infection. In this study, we screened 233 kinds of extracts of Kampo herbal medicines on the expression of hsp 70 in human lymphocytes. Among them, 7 kinds of Kampo herbal medicine extracts, namely Carthami Flos, Corni Fructus, Crataegi Fructus, Dianthi Herba, Euphorbiae Kansui Radix, Scutellariae Radix and Sojae Semen Praeparatum, increased hsp 70 expression one and half times in human lymphocytes. Among those, 6 kinds of extracts were confirmed to increase it in a dose-dependent manner. From these results, it was proved that some Kampo herbal medicines have the ability to control the expression of hsp 70, and it was suggested that these herbs could be applicable for the treatment of various diseases in which the hsp system participates. (author abst.) |
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