Anti-invasive effects of curcuminoid compounds from Curcuma aromatica Salisb. on murine colon 26-L5 carcinoma cells.
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Accession number;03A0126863
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| Title;Anti-invasive effects of curcuminoid compounds from Curcuma aromatica Salisb. on murine colon 26-L5 carcinoma cells. |
| Author;
SIRIPONG P
(National Cancer Inst., Bangkok, Tha)
NAKAMURA E S
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
KANOKMEDHAKUL K
(Khon Kaen Univ., Khon Kaen, Tha)
RUCHIRAWAT S
(Mahidol Univ., Bangkok, Tha)
SAIKI I
(Toyama Medical And Pharmaceutical Univ., Toyama, Jpn)
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Journal Title;Journal of Traditional Medicines
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Journal Code:Y0941A
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ISSN:1340-6302
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VOL.19;NO.6;PAGE.209-215(2002)
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| Figure&Table&Reference;FIG.3, REF.32 |
| Pub. Country;Japan |
| Language;English |
| Abstract;Bioassay-directed fractionation of the active chloroform extract from the rhizomes of Curcuma aromatica Salisb. (Zingiberaceae) led to the isolation of four main curcuminoid constituents: curcumin (CA-1), demethoxycurcumin (CA-2), 5'-methoxycurcumin (CA-3) and bisdemethoxycurcumin (CA-4). This is the first report to describe the isolation of CA-3 from C. aromatica. The chemical structures of these compounds were determined on the basis of spectral analysis and their inhibitory effects on the proliferation, invasion and migration of murine colon 26-L5 adenocarcinoma cells were evaluated in vitro. Curcumin and its analogues (CA-2, 3 and 4), at the non-cytotoxic concentration of 10 .MU.M, inhibited the invasive ability of colon 26-L5 cells to the ranges of 22.8, 28.9, 10.3 and 62.0%, respectively. A similar effect of these constituents on the migration of colon 26-L5 cells was also observed. Among these curcuminoids, CA-4 showed the strongest activities, inhibiting both tumor cell invasion and migration in a concentration-dependent manner. (author abst.) |
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